Season 1 1979 - 1980

Plastic Man takes on the Weed, a walking sentient plant who robs a university of its plant growth formula in order to create his own plant monster in order to take over the world's capitals, starting with Lima, Peru. The Weed fails to realize his mutated plant monster may not behave like other plants.

A sentient clam with a pirate captain-motif, called "The Clam" steals a water-controlling machine from the Chinese government. The Chief tells Plastic Man the machine is in Italy, however, that was a false report by the Clam's hoods, leaving New York City undefended for the Clam to make a tsunami, evacuating NYC and flooding it completely except for the top floors of the tallest buildings, allowing the Clam and his underlings to commit robberies as all the banks and department stores are now submerged.

While working on a secret government project, Professor Darwin's experiment goes very wrong. The mistake is costly as it leaves Professor Darwin (quite literally) half ape and half human. As Half-Ape, he plans to steal a visiting flying saucer to start an interplanetary war.

A group of small gangsters called the Miniscule 7 plot to win basketball tournaments their way. It's up to Plastic Man to stop them.

Dr. Superstein plots to steal the minds of people to power his monster army.

Doctor Dome discovers a way to extract Plastic Man's superpowers and uses them to commit crimes.

Doctor Dinosaur uses his dinosaurs to help rob banks and national landmarks.

An airplane carrying the children of an important official crashes in the forbidden zone of Stone Island, which is run by a sinister group known as the Empire of Evil. Plastic Man and his friends are sent to rescue the children and return them to safety.

Computerhead is an evil robot that has developed a device that can bring any machine to life. He then sets out to create an army of machines to take over the world.

Plastic Man must make a plan to stop an evil genie that is abducting teenagers at an alarming rate. The genie grants wishes to teenagers that want to win. He then turns them into a statue of gold and takes them for his collection, and his next target is Penny's nephew who is in a track & field competition. Plastic-Man had once fought Badladdin before, and the villain is determined not to lose a rematch.

Plastic Man learns that Ghost Finger has returned to get revenge on the people responsible for sending him to prison. He uses a time machine to bring other evil ghost from the past in to help him get his revenge.

Kitty Katt discovers an Egyptian serum that can turn anyone into cats.

Solex uses his solar weapon to spring Weed, Half-Ape, Clam, Computerhead, and Disco Mummy from prison in order to lead them. However, they don't agree with his terms. When Solex starts disrupting their crimes, the five villains turn to Plastic Man for help.

Doctor Duplicator is kidnapping politicians and replacing them with evil duplicate clones in order to steal government secrets.

Count Graffiti wants revenge on the Royal Family of Ocentania after being exiled from the country. He plans on stealing the royal crown in order to make himself the new king, but Plastic Man has other ideas and plans on stopping his scheme.

An ancient Aztec Queen called Disco Mummy comes back to life and steals the ancient treasure of Cortez from the government of Mexico. She tricks Plastic Man into helping her and then turns him into a mummy. He must find a way out if he is to have a chance to stop her.